S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes
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منابع مشابه
S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver.
Methionine metabolism starts with the formation of S-adenosylmethionine (AdoMet), the most important biological methyl donor. This reaction is catalyzed by methionine adenosyltransferase (MAT). MAT is the product of two different genes: MAT1A, which is expressed only in the adult liver, and MAT2A, which is widely distributed, expressed in the fetal liver, and replaces MAT1A in hepatocarcinoma. ...
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Genome sequence analysis reveals that all organisms synthesize S-adenosylmethionine (AdoMet) and that a large fraction of all genes is AdoMet-dependent methyltransferases. AdoMet-dependent methylation has been shown to be central to many biological processes. Up to 85% of all methylation reactions and as much as 48% of methionine metabolism occur in the liver, which indicates the crucial import...
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Shapiro, Stanley K. (Argonne National Laboratory, Argonne, Ill.). Utilization of S-adenosylmethionine by microorganisms. J. Bacteriol. 83:169-174. 1962.-Two types of mutants of Aerobacter aerogenes that utilize S-adenosylmethionine for growth are described. One type also responds to methionine, 5'methylthioadenosine, or a combination of homocysteine and S-methylmethionine. The second type of mu...
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S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be taken up intact by cells. S-Adenosylhomocysteine (AdoHcy), formed after donation of the methyl group of AdoMet to a methyl acceptor, is then hydrolyze...
متن کاملRadical S-Adenosylmethionine Enzymes
ing a H-atom from substrate. These and other kinetics studies demonstrated that PFL-AE could undergo multiple turnover events, with the 150 PFL activations per PFL-AE reported in Table 1 not the upper limit, but rather a number limited by the PFL:PFL-AE ratio in the steady-state kinetics assays. As can be seen from the data summarized in Table 1, PFL-AE is one of the few radical SAM enzymes dem...
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ژورنال
عنوان ژورنال: European Journal of Cell Biology
سال: 2011
ISSN: 0171-9335
DOI: 10.1016/j.ejcb.2010.09.007